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Treatment for Benzodiazepine Withdrawal
by Charles Gant, N.M.D., Ph.D.
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(This protocol should not be used in place of a recommended
treatment provided by your health care provider and should
only be used with their approval. I have found this
protocol to be useful for many of my patients but I cannot
guarantee that it will be effective for everyone.
Normally, I would recommend a full integrative medicine workup
including amino acid plasma levels, RBC minerals, essential
fatty acids and other diagnostic testing to determine
precisely which of the interventions noted here are actually
Benzodiazepines are a class of drugs often used as tranquilizers. Full information on
"benzo" problems is available at www.benzosupport.org
Here is my current and ever-changing protocol for benzodiazepine withdrawal.
1) GABA 500 to 2000 mg., two or three times a day (GABA, like tyrosine, may not cross the BBB unless the patient is very stressed and it appears that the studies that suggest that GABA does not cross were done on unstressed subjects.)
2) Theanine 200 to 600 mg., two or three time a day (Theanine competes with glutamate receptors to mitigate the neuroexcitatory effects. In another elegant balancing mechanism, the brain balances glutamate (excitatory) which is made into the generally inhibitory GABA (requires B6) The theanine in green tea may be one reason that the also present caffeine does not seem to stimulate tea drinkers as much.)
3) P5P (pyridoxal-5-phosphate) 50 mg. - One capsule two or three times a day (Some people don't phosphorylate B6 well).
4) Glutamine powder - One level teaspoonful twice a day to three heaping teaspoonfuls a day, dissolved in water, one hour before meals, last dose at bedtime (Especially important for hypoglycemic patients, as glutamine deficiency is by far the main immediate cause of hypoglycemia and glutamine is the precursor for glutamate).
5) Magnesium taurate - 1000 mg. twice a day to 2000 mg. three time a day
6) Salt food lightly with NuSalt/NoSalt (potassium chloride)
7) 5HTP - 100 mg. twice a day to 200 mg. three times a day
8) Purified soy lecithin - 1000 mg. three times a day (B5
(pantethine (not pantothenic acid) needed to acetylate the choline to
acetylcholine, generally relaxing and downregulating of
9) Pantethine 500 mg. - One twice a day
10) Optizinc - 20-30 mg. twice a day. (Lowers the commonly high copper, which inhibits 5HTP
decarboxylase. Activates digestive enzymes to help with amino acid absorption.)
11) Lipoic acid - 300 mg. twice a day (oral chelation for neuroexcitatory heavy metals, especially mercury)
13) Distilled fish oil (omega 3) 4000 mg a day and Borage oil (omega 6) 1000 mg. a day (Essential fatty acids ultimately increase the neuroplasticity of cell membranes, possibly assisting receptor activity).
14) Add herbal "sedatives" if necessary
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